SNIP1, Smad nuclear interacting protein 1

SNIP1, Smad nuclear interacting protein 1

• This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The encoded protein also regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression. Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED). [provided by RefSeq, Mar 2012]

• Gene Synonyms (smad nuclear-interacting protein 1, FHA domain-containing protein SNIP1, PML1 homolog, PML1, PMRED,)
• NCBI Gene ID: 79753
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8TAD8
  UNIPROT ID#>>B1AK66
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Smad nuclear interacting protein 1 interacts with:

• coiled-coil domain containing 12
  fermitin family member 3
  HAUS augmin-like complex, subunit 4
  homeodomain interacting protein kinase 1
  keratin associated protein 10-6
  poly(A) binding protein interacting protein 2B
  serine and arginine rich splicing factor 12
  serine/arginine repetitive matrix 4
  SPANX family member N2
  SPT2 chromatin protein domain containing 1
  tetratricopeptide repeat domain 14
  YTH domain containing 1
  zinc finger and BTB domain containing 9
  zinc finger CCCH-type containing 14
  zinc finger CCHC-type containing 7

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.