HM13, histocompatibility minor 13

HM13, histocompatibility minor 13

• The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (minor histocompatibility antigen H13, intramembrane protease 1, minor histocompatibility antigen 13, presenilin-like protein 3, signal peptide peptidase beta, signal peptide peptidase like 1, H13, IMP1, IMPAS, IMPAS-1, MSTP086, PSENL3, PSL3, SPP, SPPL1,)
• NCBI Gene ID: 81502
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0C4DGU3
  UNIPROT ID#>>A0A0S2Z5V7
  UNIPROT ID#>>Q8TCT9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

histocompatibility minor 13 interacts with:

• leucine zipper tumor suppressor 2
  stimulator of interferon response cGAMP interactor 1
  transmembrane protein 17
  transmembrane protein 266
  transmembrane protein 67
  UBA domain containing 2
  unc-93 homolog B1, TLR signaling regulator

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.