RNF170, ring finger protein 170

RNF170, ring finger protein 170

• This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]

• Gene Synonyms (E3 ubiquitin-protein ligase RNF170, RING-type E3 ubiquitin transferase RNF170, putative LAG1-interacting protein, ADSA, SNAX1,)
• NCBI Gene ID: 81790
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96K19
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ring finger protein 170 interacts with:

• charged multivesicular body protein 4B
  claspin
  DnaJ heat shock protein family (Hsp40) member C30
  F-box protein 21
  FXYD6-FXYD2 readthrough
  par-6 family cell polarity regulator beta
  phospholipid phosphatase 6
  reticulophagy regulator family member 3
  ring finger protein 170
  solute carrier family 35 member B2
  synaptosome associated protein 47
  ubiquitin conjugating enzyme E2 U

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.