SYN3, synapsin III

SYN3, synapsin III

• This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. The protein encoded by this gene shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. The protein contains a unique domain J, located between domains C and E. Based on this gene's localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The TIMP3 gene is located within an intron of this gene and is transcribed in the opposite direction. Alternative splicing of this gene results in multiple splice variants that encode different isoforms. [provided by RefSeq, Oct 2008]

• Gene Synonyms (synapsin-3, cN28H9.2 (synapsin III),)
• NCBI Gene ID: 8224
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O14994
  UNIPROT ID#>>A0A024R1I8
  UNIPROT ID#>>Q59EX7
  UNIPROT ID#>>Q17R54
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

synapsin III interacts with:

• C9orf72-SMCR8 complex subunit
  mortality factor 4 like 1
  mortality factor 4 like 2
  nitric oxide synthase 1 adaptor protein
  protein inhibitor of activated STAT 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.