POMK, protein O-mannose kinase

POMK, protein O-mannose kinase

• This gene encodes a protein that may be involved in the presentation of the laminin-binding O-linked carbohydrate chain of alpha-dystroglycan (a-DG), which forms transmembrane linkages between the extracellular matrix and the exoskeleton. Some pathogens use this O-linked carbohydrate unit for host entry. Loss of function compound heterozygous mutations in this gene were found in a human patient affected by the Walker-Warburg syndrome (WWS) phenotype. Mice lacking this gene contain misplaced neurons (heterotopia) in some regions of the brain, possibly from defects in neuronal migration. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

• Gene Synonyms (protein O-mannose kinase, Sugen kinase 196, probable inactive protein kinase-like protein SgK196, protein kinase-like protein SgK196, MDDGA12, MDDGC12, SGK196,)
• NCBI Gene ID: 84197
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9H5K3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein O-mannose kinase interacts with:

• adhesion G protein-coupled receptor G5
  ALG10 alpha-1,2-glucosyltransferase
  ceramide synthase 6
  cytochrome b5 domain containing 2
  divergent protein kinase domain 1A
  fat storage inducing transmembrane protein 2
  membrane spanning 4-domains A13
  phosphatidylinositol glycan anchor biosynthesis class M
  post-GPI attachment to proteins GalNAc transferase 4
  protein kinase domain containing, cytoplasmic
  RBM14-RBM4 readthrough
  reticulophagy regulator family member 3
  TLC domain containing 4
  transmembrane protein 120B
  transmembrane protein with metallophosphoesterase domain
  tRNA-yW synthesizing protein 1 homolog B
  ubiquitin specific peptidase 30

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.