RSPO3, R-spondin 3

RSPO3, R-spondin 3

• This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013]

• Gene Synonyms (R-spondin-3, R-spondin 3 homolog, protein with TSP type-1 repeat, roof plate-specific spondin-3, thrombospondin type-1 domain-containing protein 2, thrombospondin, type I, domain containing 2, CRISTIN1, PWTSR, THSD2,)
• NCBI Gene ID: 84870
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9BXY4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

R-spondin 3 interacts with:

• dpy-19 like C-mannosyltransferase 3
  metadherin

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.