ORAI1, ORAI calcium release-activated calcium modulator 1

ORAI1, ORAI calcium release-activated calcium modulator 1

• The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]

• Gene Synonyms (calcium release-activated calcium channel protein 1, calcium release-activated calcium modulator 1, protein orai-1, transmembrane protein 142A, CRACM1, IMD9, ORAT1, TAM2, TMEM142A,)
• NCBI Gene ID: 84876
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96D31
  UNIPROT ID#>>A0A024RBT3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ORAI calcium release-activated calcium modulator 1 interacts with:

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.