USP45, ubiquitin specific peptidase 45

USP45, ubiquitin specific peptidase 45

• The protein encoded by this gene is a deubiquitylase that binds ERCC1, the catalytic subunit of the XPF-ERCC1 DNA repair endonuclease. This endonuclease is a critical regulator of DNA repair processes, and the deubiquitylase activity of the encoded protein is important for maintaining the DNA repair ability of XPF-ERCC1. [provided by RefSeq, Sep 2016]

• Gene Synonyms (ubiquitin carboxyl-terminal hydrolase 45, deubiquitinating enzyme 45, ubiquitin specific protease 45, ubiquitin thioesterase 45, ubiquitin thiolesterase 45, ubiquitin-specific-processing protease 45, LCA19,)
• NCBI Gene ID: 85015
• Species: Homo sapiens (Human)
• UNIPROT ID#>>D6RBV3
  UNIPROT ID#>>Q70EL2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin specific peptidase 45 interacts with:

• myosin light chain 12B
  protein kinase, AMP-activated, alpha 1 catalytic subunit

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.