SOCS1, suppressor of cytokine signaling 1

SOCS1, suppressor of cytokine signaling 1

• This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]

• Gene Synonyms (suppressor of cytokine signaling 1, JAK binding protein, STAT induced SH3 protein 1, STAT-induced STAT inhibitor 1, Tec-interacting protein 3, cytokine-inducible SH2 protein 1, CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP-3, TIP3,)
• NCBI Gene ID: 8651
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O15524
  UNIPROT ID#>>Q4JHT5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

suppressor of cytokine signaling 1 interacts with:

• alpha tubulin acetyltransferase 1
  ankyrin repeat and SOCS box containing 3
  copper metabolism domain containing 1
  C-type lectin domain containing 7A
  CUE domain containing 2
  cullin associated and neddylation dissociated 1
  cytohesin 1 interacting protein
  elongation factor Tu GTP binding domain containing 2
  insulin receptor substrate 2
  Josephin domain containing 1
  leucine rich repeat containing 41
  nectin cell adhesion molecule 3
  nectin cell adhesion molecule 4
  Pim-2 proto-oncogene, serine/threonine kinase
  ring-box 1
  suppressor of cytokine signaling 2
  thyroid hormone receptor associated protein 3
  TIR domain containing adaptor protein
  tripartite motif containing 5
  tripartite motif containing 8
  tRNA methyltransferase 10C, mitochondrial RNase P subunit
  WD repeat and SOCS box containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.