HERC3, HECT and RLD domain containing E3 ubiquitin protein ligase 3

HERC3, HECT and RLD domain containing E3 ubiquitin protein ligase 3

• This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]

• Gene Synonyms (probable E3 ubiquitin-protein ligase HERC3, HECT domain and RCC1-like domain-containing protein 3, HECT-type E3 ubiquitin transferase HERC3, hect domain and RLD 3,)
• NCBI Gene ID: 8916
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4DK41
  UNIPROT ID#>>Q15034
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

HECT and RLD domain containing E3 ubiquitin protein ligase 3 interacts with:

• cytochrome P450 family 39 subfamily A member 1
  family with sequence similarity 189 member A2
  family with sequence similarity 189 member B
  F-box and WD repeat domain containing 11
  guanine deaminase
  H3.2 histone (putative)
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
  interleukin 17 receptor C
  monoacylglycerol O-acyltransferase 2
  nuclear RNA export factor 1
  NudC domain containing 2
  POTE ankyrin domain family member C
  RCC1 and BTB domain containing protein 1
  Rho GTPase activating protein 25
  rhomboid like 1
  solute carrier family 25 member 2
  transmembrane O-mannosyltransferase targeting cadherins 4
  transmembrane protein 62
  tripartite motif containing 14
  tubulin tyrosine ligase like 2
  ubiquilin 1
  ubiquilin 2
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.