UBE3B, ubiquitin protein ligase E3B

UBE3B, ubiquitin protein ligase E3B

• The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. This gene encodes a member of the E3 ubiquitin-conjugating enzyme family which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and transfers the ubiquitin to the targeted substrates. A HECT (homology to E6-AP C-terminus) domain in the C-terminus of the longer isoform of this protein is the catalytic site of ubiquitin transfer and forms a complex with E2 conjugases. Shorter isoforms of this protein which lack the C-terminal HECT domain are therefore unlikely to bind E2 enzymes. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2012]

• Gene Synonyms (ubiquitin-protein ligase E3B, HECT-type ubiquitin transferase E3B, BPIDS, KOS,)
• NCBI Gene ID: 89910
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024RBI2
  UNIPROT ID#>>Q7Z3V4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin protein ligase E3B interacts with:

• oxidoreductase NAD-binding domain containing 1
  ubiquitin protein ligase E3B

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