CLDN2, claudin 2

CLDN2, claudin 2

• This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.[provided by RefSeq, Jan 2010]

• Gene Synonyms (claudin-2, SP82,)
• NCBI Gene ID: 9075
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P57739
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

claudin 2 interacts with:

• ADAM metallopeptidase domain 33
  butyrophilin subfamily 3 member A2
  chondroitin sulfate N-acetylgalactosaminyltransferase 2
  C-type lectin domain family 2 member D
  cysteine rich tail 1
  family with sequence similarity 209 member A
  interleukin 27 receptor subunit alpha
  keratin associated protein 10-3
  keratin associated protein 1-1
  keratin associated protein 1-3
  keratin associated protein 4-12
  ligand of numb-protein X 1
  linker for activation of T cells
  lysophosphatidic acid receptor 3
  metadherin
  notch 2 N-terminal like A
  testis expressed 264, ER-phagy receptor
  tight junction protein 2
  transmembrane protein 218
  WNK lysine deficient protein kinase 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.