DIRAS3, DIRAS family GTPase 3

DIRAS3, DIRAS family GTPase 3

• This gene encodes a member of the ras superfamily. This gene is imprinted gene with monoallelic expression of the paternal allele which is associated with growth suppression. The encoded protein acts as a tumor suppressor whose function is abrogated in many ovarian and breast cancers. This protein may also play a role autophagy in certain cancer cells by regulating the autophagosome initiation complex. [provided by RefSeq, Nov 2015]

• Gene Synonyms (GTP-binding protein Di-Ras3, DIRAS family, GTP-binding RAS-like 3, distinct subgroup of the Ras family member 3, ras homolog gene family, member I, rho-related GTP-binding protein RhoI, ARHI, NOEY2,)
• NCBI Gene ID: 9077
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O95661
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DIRAS family GTPase 3 interacts with:

• autophagy related 14
  BAG cochaperone 4
  BRMS1 transcriptional repressor and anoikis regulator
  checkpoint kinase 2
  DDB1 and CUL4 associated factor 10
  fasciculation and elongation protein zeta 2
  HECT domain E3 ubiquitin protein ligase 1
  partner and localizer of BRCA2
  ring finger protein 19B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.