DLG5, discs large MAGUK scaffold protein 5

DLG5, discs large MAGUK scaffold protein 5

• This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]

• Gene Synonyms (disks large homolog 5, discs large protein LP-DLG, discs large protein P-dlg, discs, large homolog 5, large type of P-DLG, placenta and prostate DLG, LP-DLG, P-DLG5, PDLG,)
• NCBI Gene ID: 9231
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8TDM6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

discs large MAGUK scaffold protein 5 interacts with:

• agrin
  BAG cochaperone 5
  BTB domain containing 10
  centriolin
  centrosomal protein 104
  centrosomal protein 128
  centrosomal protein 135
  centrosomal protein 135
  centrosomal protein 152
  centrosomal protein 43
  centrosomal protein 89
  hook microtubule tethering protein 3
  mediator complex subunit 4
  myosin, heavy polypeptide 9, non-muscle
  N(alpha)-acetyltransferase 11, NatA catalytic subunit
  ninein like
  RPGR interacting protein 1
  SAS-6 centriolar assembly protein
  sorbin and SH3 domain containing 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.