- Gene Overview
- Interaction Network
- Sequence Verification
ADAMTS2, ADAM metallopeptidase with thrombospondin type 1 motif 2
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This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature procollagen N-proteinase. This proteinase excises the N-propeptide of the fibrillar procollagens types I-III and type V. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
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Gene Synonyms (A disintegrin and metalloproteinase with thrombospondin motifs 2, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2, procollagen I N-proteinase, procollagen I/II amino propeptide-processing enzyme, procollagen N-endopeptidase, ADAM-TS2, ADAMTS-2, ADAMTS-3, EDSDERMS, NPI, PC I-NP, PCI-NP, PCINP, PCPNI, PNPI,)
- NCBI Gene ID:
9509
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>O95450
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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ADAM metallopeptidase with thrombospondin type 1 motif 2 interacts with:
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