NR1I3, nuclear receptor subfamily 1 group I member 3

NR1I3, nuclear receptor subfamily 1 group I member 3

• This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (nuclear receptor subfamily 1 group I member 3, constitutive activator of retinoid response, constitutive active receptor, constitutive active response, constitutive androstane nuclear receptor variant 2, constitutive androstane nuclear receptor variant 3, constitutive androstane nuclear receptor variant 4, constitutive androstane nuclear receptor variant 5, constitutive androstane receptor, orphan nuclear hormone receptor, orphan nuclear receptor MB67, CAR, CAR1, MB67,)
• NCBI Gene ID: 9970
• Species: Homo sapiens (Human)
• UNIPROT ID#>>F1DAL4
  UNIPROT ID#>>Q14994
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

nuclear receptor subfamily 1 group I member 3 interacts with:

• chromodomain helicase DNA binding protein 9
  DNA methyltransferase 3 like
  mediator complex subunit 15
  mediator complex subunit 4
  nuclear receptor coactivator 2
  PPARG coactivator 1 alpha
  protein kinase D2
  sorting nexin 13

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.