RASGRP1, RAS guanyl releasing protein 1

RASGRP1, RAS guanyl releasing protein 1

• This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]

• Gene Synonyms (RAS guanyl-releasing protein 1, RAS guanyl nucleotide-releasing protein 1, RAS guanyl releasing protein 1 (calcium and DAG-regulated), calcium and DAG-regulated guanine nucleotide exchange factor II, calcium- and diacylglycerol-regulated guanine nucleotide exchange factor II, guanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1A, ras activator RasGRP, CALDAG-GEFI, CALDAG-GEFII, IMD64, RASGRP,)
• NCBI Gene ID: 10125
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O95267
  UNIPROT ID#>>B2RA89
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

RAS guanyl releasing protein 1 interacts with:

• ATP binding cassette subfamily B member 8

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.