CELA3A, chymotrypsin like elastase 3A

CELA3A, chymotrypsin like elastase 3A

• Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3A has little elastolytic activity. Like most of the human elastases, elastase 3A is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1. [provided by RefSeq, Jul 2008]

• Gene Synonyms (chymotrypsin-like elastase family member 3A, chymotrypsin like elastase family member 3A, elastase 1, elastase 3A, pancreatic, elastase IIIA, elastase-3A, protease E, ELA3, ELA3A,)
• NCBI Gene ID: 10136
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P09093
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

chymotrypsin like elastase 3A interacts with:

• angiotensin II receptor associated protein
  cAMP responsive element binding protein 3
  contactin associated protein family member 3
  diphosphoinositol pentakisphosphate kinase 2
  F-box protein 7
  POTE ankyrin domain family member F
  transmembrane protein 132A
  tubulin beta 8 class VIII

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.