RASA4, RAS p21 protein activator 4

RASA4, RAS p21 protein activator 4

• This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (ras GTPase-activating protein 4, Ca2+-promoted Ras inactivator, calcium-promoted Ras inactivator, rasGAP-activating-like protein 2, CAPRI, GAPL,)
• NCBI Gene ID: 10156
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O43374
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

RAS p21 protein activator 4 interacts with:

• adipocyte plasma membrane associated protein
  CDC like kinase 4
  Jupiter microtubule associated homolog 2
  protein arginine methyltransferase 8

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.