GPNMB, glycoprotein nmb

GPNMB, glycoprotein nmb

• The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (HGFIN, NMB, PLCA3, transmembrane glycoprotein NMB, glycoprotein (transmembrane) nmb, glycoprotein nmb-like protein, glycoprotein nonmetastatic melanoma protein B, hematopoietic growth factor inducible neurokinin-1, hematopoietic growth factor inducible neurokinin-1 type, osteoactivin, transmembrane glycoprotein HGFIN,)
• NCBI Gene ID: 10457
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q14956
  UNIPROT ID#>>A0A024RA55
  UNIPROT ID#>>Q96F58
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

glycoprotein nmb interacts with:

• F-box and leucine rich repeat protein 4
  interleukin 31 receptor A
  intersectin 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.