PDIA5, protein disulfide isomerase family A member 5

PDIA5, protein disulfide isomerase family A member 5

• This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. The N-terminal TRX-like domain is the primary binding site for the major ER chaperone calreticulin and possibly other proteins and substrates as well. Alternative splicing results in multiple protein- and non-protein-coding transcript variants. [provided by RefSeq, Dec 2016]

• Gene Synonyms (PDIR, protein disulfide-isomerase A5, protein disulfide isomerase-associated 5, protein disulfide isomerase-related protein,)
• NCBI Gene ID: 10954
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q14554
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein disulfide isomerase family A member 5 interacts with:

• ADP dependent glucokinase
  ANTXR cell adhesion molecule 1
  autophagy related 16 like 1
  cutA divalent cation tolerance homolog
  keratin associated protein 10-3
  keratin associated protein 10-7
  keratin associated protein 1-3
  mucin like 1
  neudesin neurotrophic factor
  neurotrimin
  pre-mRNA processing factor 19
  stromal cell derived factor 2 like 1
  TNFAIP3 interacting protein 2
  ubiquilin 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.