LDB3, LIM domain binding 3

LDB3, LIM domain binding 3

• This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains. [provided by RefSeq, Jan 2010]

• Gene Synonyms (LIM domain-binding protein 3, PDZ and LIM domain 6, Z-band alternatively spliced PDZ-motif protein, cardiomyopathy, dilated 1C (autosomal dominant), protein cypher, CMD1C, CMH24, CMPD3, CYPHER, LDB3Z1, LDB3Z4, LVNC3, MFM4, ORACLE, PDLIM6, ZASP,)
• NCBI Gene ID: 11155
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O75112
  UNIPROT ID#>>A0A0S2Z501
  UNIPROT ID#>>A0A0S2Z530
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

LIM domain binding 3 interacts with:

• ankyrin repeat domain 2
  myozenin 1
  myozenin 2
  myozenin 3

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