TXNRD3, thioredoxin reductase 3

TXNRD3, thioredoxin reductase 3

• The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes the third TrxR, which unlike the other two isozymes, contains an additional N-terminal glutaredoxin (Grx) domain, and shows highest expression in testis. The Grx domain allows this isozyme to participate in both Trx and glutathione systems. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. Experimental evidence suggests the use of a non-AUG (CUG) codon as a translation initiation codon (PMID:20018845). [provided by RefSeq, Aug 2017]

• Gene Synonyms (TGR, TR2, TR2IT1, TRXR3, TXNRD3IT1, TXNRD3NB, TXNRD3NT1, thioredoxin reductase 3, TXNRD3 neighbor gene protein, thioredoxin and glutathione reductase, thioredoxin glutathione reductase, thioredoxin reductase 2, thioredoxin reductase 2 intronic transcript 1, thioredoxin reductase 3 intronic transcript 1, thioredoxin reductase 3 neighbor, thioredoxin reductase 3 neighbor gene protein, thioredoxin reductase 3 new transcript 1, thioredoxin reductase TR2,)
• NCBI Gene ID: 114112
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4DRZ5
  UNIPROT ID#>>Q86VQ6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

thioredoxin reductase 3 interacts with:

• bolA family member 2
  bolA family member 2B
  parkin coregulated like

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