FGD4, FYVE, RhoGEF and PH domain containing 4

FGD4, FYVE, RhoGEF and PH domain containing 4

• This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]

• Gene Synonyms (CMT4H, FRABP, ZFYVE6, FYVE, RhoGEF and PH domain-containing protein 4, FGD1 family, member 4, FGD1-related F-actin-binding protein, actin-filament binding protein frabin, zinc finger FYVE domain-containing protein 6,)
• NCBI Gene ID: 121512
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q49A55
  UNIPROT ID#>>B7Z493
  UNIPROT ID#>>F8W1R0
  UNIPROT ID#>>Q96M96
  UNIPROT ID#>>B7Z8F9
  UNIPROT ID#>>E9PJX4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

FYVE, RhoGEF and PH domain containing 4 interacts with:

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