ALKBH2, alkB homolog 2, alpha-ketoglutarate dependent dioxygenase

ALKBH2, alkB homolog 2, alpha-ketoglutarate dependent dioxygenase

• The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]

• Gene Synonyms (ABH2, DNA oxidative demethylase ALKBH2, 2OG-Fe(II) oxy DC1, alkB, alkylation repair homolog 2, alkylated DNA repair protein alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase alkB homolog 2, oxy DC1,)
• NCBI Gene ID: 121642
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6NS38
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

alkB homolog 2, alpha-ketoglutarate dependent dioxygenase interacts with:

• kinesin family member 19A
  lipocalin 15
  sestrin 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.