KRT80, keratin 80

KRT80, keratin 80

• Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene's expression profile shows that it encodes a type II epithelial keratin, although structurally the encoded protein is more like a type II hair keratin. This protein is involved in cell differentiation, localizing near desmosomal plaques in earlier stages of differentiation but then dispersing throughout the cytoplasm in terminally differentiating cells. The type II keratins are clustered in a region of chromosome 12q13. Two transcript variants encoding two different fully functional isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

• Gene Synonyms (KB20, keratin, type II cytoskeletal 80, CK-80, K80, cytokeratin-80, keratin 80, type II, keratin b20, type II keratin, type-II keratin Kb20,)
• NCBI Gene ID: 144501
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6KB66
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

keratin 80 interacts with:

• keratin 24
  keratin 28
  lebercilin LCA5 like
  zinc finger containing ubiquitin peptidase 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.