A2ML1, alpha-2-macroglobulin like 1

A2ML1, alpha-2-macroglobulin like 1

• This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein is thought to be an N-glycosylated monomeric protein that acts as an inhibitor of several proteases. It has been shown to form covalent interactions with proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease paraneoplastic pemphigus (PNP; PMID:20805888). Mutations in these gene have also been associated with some cases of Noonan syndrome (NS; PMID:24939586) as well as some cases of otitis media (PMID:26121085). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

• Gene Synonyms (CPAMD9, OMS, p170, alpha-2-macroglobulin-like protein 1, C3 and PZP-like, alpha-2-macroglobulin domain containing 9,)
• NCBI Gene ID: 144568
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B3KVV6
  UNIPROT ID#>>A8K2U0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

alpha-2-macroglobulin like 1 interacts with:

• cyclin Y like 1
  NHL repeat containing 2
  solute carrier family 39 member 11

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.