UNC45B, unc-45 myosin chaperone B

UNC45B, unc-45 myosin chaperone B

• This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

• Gene Synonyms (CMYA4, CTRCT43, SMUNC45, UNC-45B, UNC45, protein unc-45 homolog B, cardiomyopathy associated 4, striated muscle UNC45, unc-45 homolog B,)
• NCBI Gene ID: 146862
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8IWX7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

unc-45 myosin chaperone B interacts with:

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