TTL, tubulin tyrosine ligase

TTL, tubulin tyrosine ligase

• TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM, Mar 2008]

• Gene Synonyms (tubulin--tyrosine ligase, 2410003M22Rik,)
• NCBI Gene ID: 150465
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8NG68
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tubulin tyrosine ligase interacts with:

• MARVEL domain containing 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.