SHISA3, shisa family member 3

SHISA3, shisa family member 3

• This gene encodes a single-transmembrane protein which is one of nine members of a family of transmembrane adaptors that modulate both WNT and FGF signaling by blocking the maturation and transport of their receptors to the cell surface. Members of this family contain an N-terminal cysteine-rich domain with a distinct cysteine pattern, a single transmembrane domain, and a C-terminal proline-rich, low complexity region. The encoded protein acts as a tumor suppressor by accelerating beta-catenin degradation. [provided by RefSeq, Jul 2017]

• Gene Synonyms (protein shisa-3 homolog, shisa homolog 3, hShisa3,)
• NCBI Gene ID: 152573
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0PJX4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

shisa family member 3 interacts with:

• ankyrin repeat domain 46

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.