NAGS, N-acetylglutamate synthase

NAGS, N-acetylglutamate synthase

• The N-acetylglutamate synthase gene encodes a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme-A. NAG is a cofactor of carbamyl phosphate synthetase I (CPSI), the first enzyme of the urea cycle in mammals. This gene may regulate ureagenesis by altering NAG availability and, thereby, CPSI activity. Deficiencies in N-acetylglutamate synthase have been associated with hyperammonemia. [provided by RefSeq, Jul 2008]

• Gene Synonyms (N-acetylglutamate synthase, mitochondrial, amino-acid acetyltransferase, AGAS, ARGA,)
• NCBI Gene ID: 162417
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q2NKP2
  UNIPROT ID#>>Q8N159
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

N-acetylglutamate synthase interacts with:

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.