Mdm4, transformed mouse 3T3 cell double minute 4

Mdm4, transformed mouse 3T3 cell double minute 4

• This gene encodes a protein that has been shown to negatively regulate the activity of the tumor suppressor protein p53. Homozygous knockout mice exhibit embryonic lethality as a result of p53-dependent apoptosis and cell cycle arrest. Amplification of this gene or overexpression of the encoded protein has been linked to a range of human cancers. A pseudogene has been identified on the X chromosome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]

• (No alternate names found)
• NCBI Gene ID: 17248
• Species: Mus musculus (Mouse)
• UNIPROT ID#>>O35618
  UNIPROT ID#>>Q3UTC9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

transformed mouse 3T3 cell double minute 4 interacts with:

• transformation related protein 53
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
  ubiquitin specific peptidase 7

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.