UBR1, ubiquitin protein ligase E3 component n-recognin 1

UBR1, ubiquitin protein ligase E3 component n-recognin 1

• The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008]

• Gene Synonyms (E3 ubiquitin-protein ligase UBR1, E3a ligase, N-recognin-1, RING-type E3 ubiquitin transferase UBR1, ubiquitin ligase E3 alpha-I, ubiquitin-protein ligase E3-alpha, ubiquitin-protein ligase E3-alpha-1, ubiquitin-protein ligase E3-alpha-I, JBS,)
• NCBI Gene ID: 197131
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8IWV7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin protein ligase E3 component n-recognin 1 interacts with:

• neuropeptide B
  protein phosphatase 1 regulatory subunit 32
  Scm polycomb group protein like 4
  spermatogenesis associated 24

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