SENP5, SUMO specific peptidase 5

SENP5, SUMO specific peptidase 5

• The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]

• Gene Synonyms (sentrin-specific protease 5, SUMO1/sentrin specific peptidase 5, SUMO1/sentrin specific protease 5, sentrin/SUMO-specific protease SENP5,)
• NCBI Gene ID: 205564
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96HI0
  UNIPROT ID#>>B2R9F5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SUMO specific peptidase 5 interacts with:

• regulator of hemoglobinization and erythroid cell expansion

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