Sptlc2, serine palmitoyltransferase, long chain base subunit 2

Sptlc2, serine palmitoyltransferase, long chain base subunit 2

• This gene encodes a long chain base subunit of serine palmitoyltransferase. The enzyme, serine palmitoyltransferase, consists of two different subunits, and is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. A mutant allele of this gene in mice is used as a model for the human disease 'Susceptibilty to Psoriasis 1'. Mutations in the human gene are associated with hereditary sensory neuropathy type I. [provided by RefSeq, Sep 2015]

• (No alternate names found)
• NCBI Gene ID: 20773
• Species: Mus musculus (Mouse)
• UNIPROT ID#>>Q542D6
  UNIPROT ID#>>P97363
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

serine palmitoyltransferase, long chain base subunit 2 interacts with:

• EF-hand calcium binding domain 5
  elongation factor like GTPase 1
  essential meiotic structure-specific endonuclease 1
  Fanconi anemia, complementation group D2
  mitochondrial rRNA methyltransferase 1
  scribble planar cell polarity protein
  WD and tetratricopeptide repeats 1
  WW domain binding protein 11

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.