Eif4g1, eukaryotic translation initiation factor 4, gamma 1

Eif4g1, eukaryotic translation initiation factor 4, gamma 1

• This gene encodes a member of the eukaryotic translation initiation factors (eIF) that play important roles in translation initiation by mediating recruitment of additional initiation factors and providing a scaffold for ribosome/mRNA-bridging. Along with eIF4A and eIF4E, the encoded protein forms the eIF4F complex that bridges the 5' UTR with the polyadenylated 3' UTR resulting in mRNA circularization, enhanced translation initiation and mRNA stability. Through its association with eIF3, the encoded protein mediates recruitment of the 43S pre-initiation complex to mRNA. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes for this gene have been identified on chromosomes 2 and 13. [provided by RefSeq, Jan 2015]

• (No alternate names found)
• NCBI Gene ID: 208643
• Species: Mus musculus (Mouse)
• UNIPROT ID#>>E9Q9E1
  UNIPROT ID#>>Q6NZJ6
  UNIPROT ID#>>E9PVC5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

eukaryotic translation initiation factor 4, gamma 1 interacts with:

• aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
  argonaute RISC catalytic subunit 1
  argonaute RISC catalytic subunit 2
  eukaryotic translation initiation factor 5
  unkempt family zinc finger

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.