TPCN2, two pore segment channel 2

TPCN2, two pore segment channel 2

• This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.[provided by RefSeq, Dec 2009]

• Gene Synonyms (two pore calcium channel protein 2, voltage-dependent calcium channel protein TPC2, SHEP10, TPC2,)
• NCBI Gene ID: 219931
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8NHX9
  UNIPROT ID#>>Q59G56
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

two pore segment channel 2 interacts with:

• diacylglycerol lipase beta
  NODAL modulator 3
  ring finger protein 149

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.