RFX6, regulatory factor X6

RFX6, regulatory factor X6

• The nuclear protein encoded by this gene is a member of the regulatory factor X (RFX) family of transcription factors. Studies in mice suggest that this gene is specifically required for the differentiation of islet cells for the production of insulin, but not for the differentiation of pancreatic polypeptide-producing cells. It regulates the transcription factors involved in beta-cell maturation and function, thus, restricting the expression of the beta-cell differentiation and specification genes. Mutations in this gene are associated with Mitchell-Riley syndrome, which is characterized by neonatal diabetes with pancreatic hypoplasia, duodenal and jejunal atresia, and gall bladder agenesis.[provided by RefSeq, Sep 2010]

• Gene Synonyms (DNA-binding protein RFX6, regulatory factor X domain-containing protein 1, regulatory factor X, 6, MTCHRS, MTFS, RFXDC1, dJ955L16.1,)
• NCBI Gene ID: 222546
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8HWS3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

regulatory factor X6 interacts with:

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