AAK1, AP2 associated kinase 1

AAK1, AP2 associated kinase 1

• Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

• Gene Synonyms (AP2-associated protein kinase 1, adaptor-associated kinase 1,)
• NCBI Gene ID: 22848
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q2M2I8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

AP2 associated kinase 1 interacts with:

• anillin actin binding protein
  ATPase cation transporting 13A2
  BICD cargo adaptor 2
  coiled-coil domain containing 88A
  DDB1 and CUL4 associated factor 15
  diphosphoinositol pentakisphosphate kinase 2
  G2 and S-phase expressed 1
  glutamine and serine rich 1
  hook microtubule tethering protein 3
  LIM domain and actin binding 1
  RALBP1 associated Eps domain containing 1
  Sec24 related gene family, member C (S. cerevisiae)
  upregulator of cell proliferation
  vir like m6A methyltransferase associated
  WNK lysine deficient protein kinase 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.