SORCS3, sortilin related VPS10 domain containing receptor 3

SORCS3, sortilin related VPS10 domain containing receptor 3

• This gene encodes a type-I receptor transmembrane protein that is a member of the vacuolar protein sorting 10 receptor family. Proteins of this family are defined by a vacuolar protein sorting 10 domain at the N-terminus. The N-terminal segment of this domain has a consensus motif for proprotein convertase processing, and the C-terminal segment of this domain is characterized by ten conserved cysteine residues. The vacuolar protein sorting 10 domain is followed by a leucine-rich segment, a transmembrane domain, and a short C-terminal cytoplasmic domain that interacts with adaptor molecules. The transcript is expressed at high levels in the brain, and candidate gene studies suggest that genetic variation in this gene is associated with Alzheimer's disease. Consistent with this observation, knockdown of the gene in cell culture results in an increase in amyloid precursor protein processing. [provided by RefSeq, Dec 2014]

• Gene Synonyms (SORCS, VPS10 domain-containing receptor SorCS3, VPS10 domain receptor protein SORCS 3 (SORCS3),)
• NCBI Gene ID: 22986
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q86XB2
  UNIPROT ID#>>Q9UPU3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

sortilin related VPS10 domain containing receptor 3 interacts with:

• RNA binding motif protein 33

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