IQSEC2, IQ motif and Sec7 domain ArfGEF 2

IQSEC2, IQ motif and Sec7 domain ArfGEF 2

• This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked cognitive disability. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

• Gene Synonyms (BRAG1, IQ-ArfGEF, MRX1, MRX18, MRX78, IQ motif and SEC7 domain-containing protein 2, IQ motif and Sec7 domain 2, brefeldin A resistant Arf-guanine nucleotide exchange factor 1, brefeldin A resistant Arf-guanine nucleotide exchange factor 1b, brefeldin A resistant Arf-guanine nucleotide exchange factor 1c, mental retardation, X-linked 18,)
• NCBI Gene ID: 23096
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A1W2PQN3
  UNIPROT ID#>>Q5JU85
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

IQ motif and Sec7 domain ArfGEF 2 interacts with:

• coiled-coil domain containing 8
  ring finger protein 123

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.