PLEKHM2, pleckstrin homology and RUN domain containing M2

PLEKHM2, pleckstrin homology and RUN domain containing M2

• This gene encodes a protein that binds the plus-end directed microtubule motor protein kinesin, together with the lysosomal GTPase Arl8, and is required for lysosomes to distribute away from the microtubule-organizing center. The encoded protein belongs to the multisubunit BLOC-one-related complex that regulates lysosome positioning. It binds a Salmonella effector protein called Salmonella induced filament A and is a critical host determinant in Salmonella pathogenesis. It has a domain architecture consisting of an N-terminal RPIP8, UNC-14, and NESCA (RUN) domain that binds kinesin-1 as well as the lysosomal GTPase Arl8, and a C-terminal pleckstrin homology domain that binds the Salmonella induced filament A effector protein. Naturally occurring mutations in this gene lead to abnormal localization of lysosomes, impaired autophagy flux and are associated with recessive dilated cardiomyopathy and left ventricular noncompaction. [provided by RefSeq, Feb 2017]

• Gene Synonyms (SKIP, pleckstrin homology domain-containing family M member 2, PH domain-containing family M member 2, SifA (Salmonella-induced filaments A) and kinesin-interacting protein, novel RUN and PH domain-containing protein, pleckstrin homology domain containing, family M (with RUN domain) member 2,)
• NCBI Gene ID: 23207
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q5VVD7
  UNIPROT ID#>>Q8IWE5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

pleckstrin homology and RUN domain containing M2 interacts with:

• solute carrier family 39 member 1

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