SULF1, sulfatase 1

SULF1, sulfatase 1

• This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

• Gene Synonyms (SULF-1, extracellular sulfatase Sulf-1, sulfatase FP,)
• NCBI Gene ID: 23213
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R809
  UNIPROT ID#>>Q8IWU6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

sulfatase 1 interacts with:

• cyclic GMP-AMP synthase
  leucine rich repeat containing 4C
  lysozyme like 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.