TGDS, TDP-glucose 4,6-dehydratase

TGDS, TDP-glucose 4,6-dehydratase

• The protein encoded by this gene is a member of the short-chain dehydrogenases/reductases (SDR) superfamily, and is thought to contain a nicotinamide adenine dinucleotide (NAD) binding domain. This large SDR family of enzymes is involved in the metabolism of a variety of compounds, including prostaglandins, retinoids, lipids, steroid hormones, and xenobiotics. Mutations in this gene have been associated with Catel-Manzke syndrome, which is characterized by Pierre Robin sequence, and radial deviation of the index finger due to the presence of an accessory bone between the index finger and its proximal phalanx. Pierre Robin sequence is defined by an undersized jaw, backwards displacement of the tongue base that causes an obstruction of the airways, and can also be associated with a cleft palate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

• Gene Synonyms (dTDP-D-glucose 4,6-dehydratase, growth-inhibiting protein 21, short chain dehydrogenase/reductase family 2E, member 1, CATMANS, SDR2E1, TDPGD,)
• NCBI Gene ID: 23483
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O95455
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TDP-glucose 4,6-dehydratase interacts with:

• POTE ankyrin domain family member E

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.