PLEKHG4, pleckstrin homology and RhoGEF domain containing G4

PLEKHG4, pleckstrin homology and RhoGEF domain containing G4

• The protein encoded by this gene can function as a guanine nucleotide exchange factor (GEF) and may play a role in intracellular signaling and cytoskeleton dynamics at the Golgi apparatus. Polymorphisms in the region of this gene have been found to be associated with spinocerebellar ataxia in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

• Gene Synonyms (puratrophin-1, PH domain-containing family G member 4, Purkinje cell atrophy associated protein 1, pleckstrin homology domain containing, family G (with RhoGef domain) member 4, ARHGEF44, PRTPHN1, SCA4,)
• NCBI Gene ID: 25894
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q58EX7
  UNIPROT ID#>>A0A024R6X4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

pleckstrin homology and RhoGEF domain containing G4 interacts with:

• APOBEC1 complementation factor
  armadillo repeat containing 7
  brain expressed X-linked 2
  coiled-coil domain containing 120
  coiled-coil domain containing 187
  cysteine rich hydrophobic domain 2
  dedicator of cytokinesis 5
  defective in cullin neddylation 1 domain containing 5
  deltex E3 ubiquitin ligase 2
  developmental pluripotency associated 3
  dual specificity phosphatase 13
  FAM161 centrosomal protein A
  family with sequence similarity 167 member A
  FYVE, RhoGEF and PH domain containing 2
  methionine sulfoxide reductase B3
  mitochondrial assembly of ribosomal large subunit 1
  myelin expression factor 2
  myozenin 1
  N-acetyltransferase domain containing 1
  P2Y receptor family member 8
  pre-mRNA processing factor 31
  protein phosphatase 1 regulatory subunit 32
  SET domain containing 5
  SH2 domain containing 4A
  shisa family member 6
  SMG9 nonsense mediated mRNA decay factor
  stabilizer of axonemal microtubules 1
  TBC1 domain family member 22B
  tektin 3
  terminal nucleotidyltransferase 5D
  testis expressed 264, ER-phagy receptor
  testis specific serine kinase 3
  tetratricopeptide repeat domain 23
  TNF receptor superfamily member 19
  transcription factor AP-2 delta
  ubiquitin conjugating enzyme E2 O
  VPS37C subunit of ESCRT-I
  zinc finger protein 319
  zinc finger protein 648

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.