NECAP1, NECAP endocytosis associated 1

NECAP1, NECAP endocytosis associated 1

• This gene encodes a protein containing two characteristic WXXF motifs. The encoded protein localizes to clathrin-coated vesicles, where it binds components of the adapter protein complexes and aids in endocytosis. Loss of function of this gene results in early infantile epileptic encephalopathy-21. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

• Gene Synonyms (adaptin ear-binding coat-associated protein 1, EIEE21,)
• NCBI Gene ID: 25977
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8NC96
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

NECAP endocytosis associated 1 interacts with:

• DnaJ heat shock protein family (Hsp40) member C5
  G2 and S-phase expressed 1
  leucine carboxyl methyltransferase 1
  NECAP endocytosis associated 2
  phosphoglycerate dehydrogenase
  RAB4B, member RAS oncogene family
  spermatogenesis associated 1
  ubiquitin-fold modifier conjugating enzyme 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.