STAP1, signal transducing adaptor family member 1

STAP1, signal transducing adaptor family member 1

• The protein encoded by this gene contains a proline-rich region, a pleckstrin homology (PH) domain, and a region in the carboxy terminal half with similarity to the Src Homology 2 (SH2) domain. This protein is a substrate of tyrosine-protein kinase Tec, and its interaction with tyrosine-protein kinase Tec is phosphorylation-dependent. This protein is thought to participate in a positive feedback loop by upregulating the activity of tyrosine-protein kinase Tec. Variants of this gene have been associated with autosomal-dominant hypercholesterolemia (ADH), which is characterized by elevated low-density lipoprotein cholesterol levels and in increased risk of coronary vascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

• Gene Synonyms (signal-transducing adaptor protein 1, BCR downstream-signaling protein 1, docking protein BRDG1, stem cell adaptor protein 1, BRDG1, STAP-1,)
• NCBI Gene ID: 26228
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024RD91
  UNIPROT ID#>>Q9ULZ2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

signal transducing adaptor family member 1 interacts with:

• autophagy related 16 like 1
  GRIP1 associated protein 1
  reticulophagy regulator family member 3
  SH3 domain containing kinase binding protein 1

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