FBXO25, F-box protein 25

FBXO25, F-box protein 25

• This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (F-box only protein 25, F-box protein Fbx25, FBX25,)
• NCBI Gene ID: 26260
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8TCJ0
  UNIPROT ID#>>A0A024QZ88
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

F-box protein 25 interacts with:

• 5-hydroxymethylcytosine binding, ES cell specific
  actin beta like 2
  ankyrin repeat domain 13A
  aprataxin and PNKP like factor
  ATPase family AAA domain containing 3A
  ATPase family AAA domain containing 3B
  BLOC-1 related complex subunit 5
  CDK5 regulatory subunit associated protein 2
  chromosome 19 open reading frame 57
  chromosome 7 open reading frame 50
  cullin associated and neddylation dissociated 1
  CXXC finger protein 4
  DEP domain containing MTOR interacting protein
  EP300 interacting inhibitor of differentiation 3
  epsin 1
  ETAA1 activator of ATR kinase
  F-box protein 32
  GTF2I repeat domain containing 2
  heterochromatin protein 1 binding protein 3
  inflammation and lipid regulator with UBA-like and NBR1-like domains
  inhibitor of growth family member 3
  interleukin 21
  junctional cadherin complex regulator
  LIM and cysteine rich domains 1
  LUC7 like
  methionine adenosyltransferase 2B
  myosin heavy chain 14
  myosin light chain 12B
  nuclear speckle splicing regulatory protein 1
  phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
  proline rich 15
  pyridoxamine 5'-phosphate oxidase
  rabaptin, RAB GTPase binding effector protein 2
  rhomboid domain containing 1
  RNA polymerase II associated protein 3
  SH3 domain containing kinase binding protein 1
  synaptotagmin like 2
  t-complex 10 like
  tetratricopeptide repeat domain 9C
  TNFAIP3 interacting protein 2
  transcription elongation factor A like 2
  transcription elongation factor A N-terminal and central domain containing
  translation machinery associated 7 homolog
  tropomodulin 3
  TruB pseudouridine synthase family member 1
  tubulin alpha 1c
  tubulin beta 1 class VI
  ubiquilin 1
  ubiquilin 2
  unc-45 myosin chaperone A
  uveal autoantigen with coiled-coil domains and ankyrin repeats
  WD repeat, sterile alpha motif and U-box domain containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.