GFRA1, GDNF family receptor alpha 1

GFRA1, GDNF family receptor alpha 1

• This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

• Gene Synonyms (GDNFR, GDNFRA, GFR-ALPHA-1, RET1L, RETL1, TRNR1, GDNF family receptor alpha-1, GDNFR-alpha-1, GPI-linked anchor protein, Glial cell line-derived neurotrophic factor receptor alpha, PI-linked cell-surface accessory protein, RET ligand 1, TGF-beta-related neurotrophic factor receptor 1,)
• NCBI Gene ID: 2674
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B7Z856
  UNIPROT ID#>>P56159
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

GDNF family receptor alpha 1 interacts with:

• BAG cochaperone 3
  neural cell adhesion molecule 1
  neurturin
  ret proto-oncogene
  suppressor of cytokine signaling 3

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