BBC3, BCL2 binding component 3

BBC3, BCL2 binding component 3

• This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

• Gene Synonyms (bcl-2-binding component 3, p53 up-regulated modulator of apoptosis, p53-upregulated modulator of apoptosis, JFY-1, JFY1, PUMA,)
• NCBI Gene ID: 27113
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9BXH1
  UNIPROT ID#>>Q96PG8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

BCL2 binding component 3 interacts with:

• hydroxysteroid 17-beta dehydrogenase 13
  microtubule associated protein 1 light chain 3 alpha
  Myb related transcription factor, partner of profilin
  TNFAIP3 interacting protein 2
  ubiquitin associated and SH3 domain containing B
  zinc finger protein 438

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.